Oral delivery of DNA vaccines using attenuatedSalmonella typhimuriumas carrier
نویسندگان
چکیده
منابع مشابه
Oral delivery of DNA vaccines using attenuated Salmonella typhimurium as carrier.
The efficacious delivery of eukaryotic expression plasmids to inductive cells of the immune system constitutes a key prerequisite for the generation of effective DNA vaccines. Here, we have explored the use of bacteria as vehicles to orally deliver expression plasmids. Attenuated Salmonella typhimurium aroA harbouring eukaryotic expression plasmids that encoded virulence factors of Listeria mon...
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Strategies to improve vaccine efficacy are still required. The immunogenicity of DNA vaccines is strongly improved by electroporation (EP). The skin is populated with a wide variety of immune cells, making it an attractive tissue for vaccine delivery. Here we describe a method for the EP-mediated intradermal delivery of DNA vaccines in nonhuman primates, as a model for preclinical development o...
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ژورنال
عنوان ژورنال: FEMS Immunology & Medical Microbiology
سال: 2000
ISSN: 0928-8244,1574-695X
DOI: 10.1111/j.1574-695x.2000.tb01448.x